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Jan 12 2010 05:25 PM ET
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Joey Fatone Welcomes Daughter Kloey Alexandra

Arlene Richie/JPI

It’s a second daughter for Joey Fatone and wife Kelly, the ‘NSYNC singer tells PEOPLE exclusively.

Kloey Alexandra Fatone arrived Monday evening, Jan. 11th in Orlando, Fla., weighing in at 5 lbs., 8 oz. She joins big sister Briahna Joely, 8 ½.

“Kloey’s so small,” notes the Dancing With the Stars alum. “She looks like a little doll. But she’s healthy and doing just fine.”

Not that it was an easy pregnancy. Shortly after learning that she was expecting, Kelly began fighting chronic fatigue. “She was so tired, just exhausted all the time,” Joey says of his wife of five years. “We took her to the doctors, and they found blood clots in her lungs. It was life and death.”

After a 12-day stay in the hospital — including two days in the ICU — doctors diagnosed Kelly with a rare genetic condition called methylenetetrahydrofolate reductase.

In addition to threatening the mother’s life, MTHFR increases the chances of the baby being born with chromosomal defects such as Down syndrome.

Joey, 32, says his wife took it easy throughout the pregnancy, but started experiencing a rapid heartbeat and fainting spells last week. Concerned for her health, doctors decided to induce Kelly’s labor two weeks before her due date.

After an intense delivery, everyone is now able to relax. “The blood clots have broken up, Kelly’s doing fine and Kloey is awesome,” the proud papa tells PEOPLE.

Joey says the name Kloey comes from a combination of his and Kelly’s names. As for the middle name, Alexandra? It was selected by Briahna for her new baby sister.

“I’m thrilled,” Joey says. “I’m just so happy that everyone’s healthy.”

– Steve Helling

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How terrifying!
Glad to hear all are healthy despite all the concerns and risks!
Congratulations to the whole family!

- Mrs. R. on

I am so glad that the baby came healthy and that mom is OK.

However, spelling a name differently just to be different is sill in my opinion. Just like Khloe Kardassian is spelled differently, this variation, Kloey is not working for me. If you want a unique name pick a unique name, don’t just misspell an actual name and think it’s unique.

- Beverley on

What a scare! Glad everyone’s healthy.

(I’m so not a fan of silly spelling and BOTH their kids have it. Ugh! But as everyone else says… it’s none of my business!)

- Janna on

The way they chose her name to be spelled…”Kloey”…I think that is just so fun and pretty and really makes me like the name. I think it’s really inventive and cool! I don’t care for their other daughter’s name though, mostly because of the spelling…I don’t really care for the “h” added in.

Congrats to the family!! :)

- Jennifer on

There is no wrong way to spell a name! I think kloey is cute the way it’s spelled. It’s meaningful for them because it’s spelled with joey & kelly’s name in it!

- g!na on

I’m so glad that both mom & baby are okay. Sounds scary.

I likw the name Kloey! I think it’s nice to combine Joey & Kelly. Although it’s not one of my favourites as I prefer Khloe or Chloe, I think it’s still nice.
Congrats to Joey, Kelly & big sister Briahna.

- Brooklyn on

so funny that she has the exact same name as Khloe Alexandra Kardashian.

- Laydacris on

I too am a mom to a little girl named briahna and spelled exactly like their briahna. While I can’t speak for the fatones, I can say I spelled it the way I did so she wouldn’t be called bri-ann-a. I liked bri-ahhhh-na and therefore spelled it phonetically. It definitely is problematic as NOONE spells her name right, and always calls her bri-ann-a anyways. I, however, do not find the spelling of my daughters name “weird” at all, and love that her name is spelled different. :)

- mom to a briahna on

Congrats to them both. Interesting the way they combined their names to make Kloey. Unique spelling to what’s being a more common name. I like it. :)

- robinepowell on

i love the name kloey! tho i prefer the chloe way. tho i liked how they came to the way of naming her! i love the middle name b/c it is my middle name. i am considering naming my future daughter alexandra rose!

- jacob black lover on

Congrats to Joey and Kelly! I also have MTHFR but I was never told I had an increased chance of a Down Syndrome baby even though I did have high blood pressure with all three of my pregnancies and four previous miscarriages.

- louisemom3 on

Looks like they took a K and L from Kelly’s name and took the -ey from Joey and created their daughter’s name that way. I could be wrong, but it’s just struck me as funny of how they spelled her name.

Glad to know everyone’s healthy and doing well after those health scares.

- FC on

Khloe Kardashian’s middle name is Alexandra as well.Khloe/Chloe and Alexandra are beautiful names, especially together.

- Hayley on

Congrats to them!!! Glad everyone is doing well after all those scary health issues happening!

I had no idea Joey and his wife were even expecting another baby!!! Such a cute little surprise for my day today! :)

- Rye on

Scary! Glad both are ok. (Horrible spelling though. [Cringe]!

- christina on

Kloey? Seriously, WHAT is wrong with spelling your kid’s name correctly? It’s like we’re a nation of illiterates now. We don’t need all these hooked on phonics spellings.

- Ashlyn on

I’m glad the baby is doing well. I much prefer the traditional spelling of her name though.

- cecily on

I really don’t like when parents ‘goof around’ with their kid’s names but the alternate spelling on this classical greek name is endearing when you read Joey and Kelly’s explanation for it.

- JustMe on

although i don’t like the spelling at all, i think it’s sweet that they combined both of their names, and then used a name their other daughter picked as the middle name. good to hear that both mom and baby are healthy!

- kmb on

As for the goofy spelling, at this point, I try not to stress what people name their kids. Yes, it’s wacky and unnecessary, but compared to other problems people have, a dumb name or spelling won’t ruin their life. I knew a girl named Candy Cane and she managed not to grow up to be a stripper. In fact, she’s a doctor, so Kloey, Apple, Sparrow, and Bronx could turn out fine.

- Basil on

Wow, that is good to hear that both mom and baby came out okay! Congrats to them on the new addition to their family!

- Julie on

How did I miss that they were having another babe-ee!? So happy for them both and SO glad that everything went well and that everyone is healthy and safe. Joey has always seemed like an awesome dad! Congrats to the now even bigger family :O)

- Rachel on

I’m glad mom and baby are okay, but that spelling is tacky tacky tacky.

- electra on

I really dislike “chloe” so this spelling isn’t THAT bad but I’m still not a big fan of either of his girl’s names.

I’m sure the name was the least of their worries though.. I’m glad the baby’s healthy!

- Natasha on

Congratulations to them! Glad everyone’s doing well. I’ve always been a fan of Joey’s – he seems like such a sweet guy.

Am not a fan of the creatively-spelled names, though. Surely that must be annoying for the kids as they get older, to have to constantly tell people how to spell their names. But it’s sweet that it’s Kelly and Joey’s names combined.

- Elizabeth on

I’m very glad that both mother and baby are healthy, but really hate the name (I dislike Chloe, and it’s even worse with a creative spelling).

- Sonya on

I agree with Mom to Briahna. I like how they spelled it because it helps to make her name be pronounced as they want it to be. I am not a fan of the name Chloe, and really don’t like the spelling of Kloey, but I can appreciate that it is a combo of their two names. And hey, if they like it, that’s all that matters really, so more power to them.

Congrats Joey, Kelly, and Briahna

- Jess from Ohio on

One of the biggest highights for me when I watch Toddlers&Tiaras (yeah I know) or any show on TLC involving children and their parents are the ridiculous spelling variations of common names that the kids have. They usually have more Y’s and N’s than need be.

But more importantly, I’m glad that everyone is well.

- bre on

I’m not very much into different spellings…it looks very illiterate to me. The spelling of Kloey and Brihana isn’t horrible but I’m not digging it. I would hate to grow up always havin to spell out my name to people.

congrats to them though. Bet she’s beautiful like Brihana.

- JMO on

I don’t like it when people make up a strange spelling for an established name. Sometimes it can look ok, but here it looks pretty awful.

Glad they are doing ok!!

- Anna on

I too have MTHFR and my doctor told me that it’s actually not that rare, just very under-diagnosed. She suggested that I get genetic counseling before getting pregnant.

- Zoey on

Oh don’t like the spelling of Kloey, prefer the more traditional way. But congrats! I’m sure Briana is loving the big sis status!

- daniela on

I too have the MTHFR polymorphism (the gene is MTHFR, the condition is called an MTHFR polymorphism or mutation). It’s not really rare at all – 10% of the North American population inherited a copy from both their mom and their dad, making them homozygous and thus at risk of pregnancy complications. However, the risk of this polymorphism is not tremendously large, and much of the risk to the fetus can be minimized by taking folic acid, especially if the mother’s homocystine levels are high.

You can find more information here: http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase

- Jenn on

i like the names of their kids, not the spellings -.-

- Milla on

Thank goodness they’re healthy! Man, people are so baggin’ on this name? Geez! C’mon it’s a combination of his name and her name! So it isn’t like they just made up something drastically differently. It’s pretty neat and it works. Kelly+Joey= Kloey! Cute! But yeah, I know, as a 2nd grade teacher those creatively spelled names can be a challenge or extra work but it’s ok! : ) My name is Janet & my husband’s name is Steve…I don’t know how the heck we’d get a cute name w/ our name combined! haha

- Janet on

Not personally into kre8tiv spellings, but at least, in their case, I can tell how the kids’ names are supposed to be pronounced. They’ve spelled them phonetically, which, if you want to be different, phonetic is okay. I’m just glad everyone is doing well! Poor Kelly had a horrific pregnancy, and they’re just lucky that both she and Kloey are alive and well.

- mrsh on

it’s funny how the 8 y/o has better taste than her parents already!!

- mazzie on

Congratulations to them!

Guess that will make three DWTS babies after Drew’s next little one. Helio, Joey, and Drew.

- Paige on

Very relieved to hear that Kelly is recovering and both mom and baby are doing well.

I think the health issues here should be a little more important than the way a name is spelled.

Congrats to Joey and Kelly on their new addition!

- tigerjen on

I am not a fan of either spelling of the names. Regardless of how they are spelled their names are still Chloe and Brianna. Changing the spelling does not make it anymore unique. All it does is make the child have to spell their names to people their entire lives.

- Jen on

Aw congrats! I like the name, just not the kre8tiv spelling.

- Chris on

I am happy that momma and baby are doing well…

BUT as a card carrying member of the Chloe club (since the 80′s when it wasn’t uber popular) I think spelling it Kloey is just plain awful.

A name isn’t just a collection of letters and sounds. It has an origin, an ethnicity and a meaning that goes along with it.

Chloe is Greek and means “always blossoming” or more literally “little green shoot” it has a beautiful meaning and has been spelled Chloe since the times of Greek mythology.

Kloey is from NOWHERE and means NOTHING.

I think changing it doesn’t make it cooler or more unique it makes it look like a a big fat spelling error.

- Chloe on

woah thats weird same exact name as khloe kardashian

- princess on

I like how they combined their names for hers, but she will forever be spelling her name for people. I know several other Sarah’s. One spells her name Saraha. Yes, there is an extra ‘a’ tacked to the end. I know there’s no wrong way to spell a name, but that’s taking it too far, IMO. (Also, my sister’s name is Krystofer. First off, a female named Krystofer. Secondly, changing the typical spelling. She goes by Krysti. It’s bad, too!)

The name thing she’ll get over, though. The most important thing is that everyone is healthy! Congrats to the whole family!!

- Sarah M. on

@Janet, #35 – how about Stanet…Jeve?

- michelle on

I don’t really like the spelling of Kloey either but I am the type that likes to mess around with spellings for names sometimes so I understand them doing it. For instance, Haley might be the traditional way to spell the name but I prefer Haylie. I think it looks prettier, I love names that end in IE (ususally, there are some variations I do not like!) I don’t see the big deal with changing the spelling.

- Laura on

tigerjen, I agree with you completely.

- Ashleigh on

i dont see the problem with changing the spelling of a name. When my parents were naming my sister they could not agree how to spell her name. Her name is Catelin. It is a mix of the traditional katelyn and the british( my mum is british) caitlin. The chose a c at the beginning because it is easier to do in signatures for when she was older.

So i do not see the problem in changing the spelling of a name

- olivia on

I didnt even know she was pregnant! Like the name, but not the spelling!

- sarah on

I’m a girl with the name “Aaron.” Yeah, I have to spell it for people a LOT, and I’m constantly getting things in the mail addressed to “Mr. Aaron.” But you know, it’s not the freakin’ end of the world, and it won’t be for these little girls. I kind of like the fact that there are hardly any other women out there with the exact spelling of my name…to this date, I’ve never met one! Glad to hear that Joey’s wife is doing okay, and congratulations on your new daughter!

- Aaron on

It is so sad how people continue to bag on the name, rather than just simply state how happy they are that both baby and mommy are healthy. It is the baby’s name. It will continue to be the baby’s name. Given I don’t like creative spellings or made up names for my children, but they aren’t my children. I don’t like Kloey only for the fact that it looks to much like Khloe Kardashian and then to find out that her name is Khloe Alexandra kind of ruins the name for me. But I like the combination. I really, really like the combination.

- Jessi on

Oh my gosh, Aaron – I’m married to an Erin (man) and we always get mail for Mrs. Erin… Funny! :) He goes by his middle name. His dad thought it would be cool to do an ‘Irish spelling’.

- jenny on

Yes, she’s going to have to spell her name for everyone, but guess what – I have a ‘traditional’ name with a traditional spelling, and I have to spell it out for everyone as well (if I don’t you’d be astonished with what I end up with).

I promise you, its not going to be a big deal to her and if it is – hey, she’s got a middle name…

At any rate – congrats to the happy and thankfully healthy family!

- Caroline on

Cute name, ridiculous/cruel spelling, poor girl when she’s older, lol. Congrats to her parents and big sis, didn’t know they were expecting…

- Sam and Freya's mum on

Congratulations to Kelly, Joey, and big sister Briahna! :) I’m so glad to hear that Kelly is recovering well and that baby Kloey is healthy. Briahna did a great job of picking her baby sister’s middle name – Alexandra is so pretty, and it pairs nicely with her first name. I’m sure Kloey is just as beautiful as her big sister!

- Jennifer on

The way they spelled Briahna reminds me of pirahna. Yikes!

And gazeundheit on the name of the condition Kelly had, though I did give a chuckle because the abbreviation of it kind of looks like mother-effer.

Congrats to them just the same!

- Silly Mama on

Chloe you are completely WRONG. Kloey isn’t from nowhere & it does mean something. It’s a combo of her parents names witch obviously means something to them & that’s what counts.

This little girl & her mom are healthy after surviving a very dangerous pregnancy & all most of you can do can do is bitch & moan about how they spelled her name.

- QT on

Glad that everyone is ok. Concerning the spelling I can imagine that here in Germany, Kloey would have a hard time… “Klo” means “toilet” here. Still love the sound of her name and she lives in the States, so who cares?

- Rikki on

I like her name and meaningful spelling. I feel bad that Kelly had such a hard pregnancy but i wish them all the best.

- Luna on

The spelling of the name looks like it should be pronounced Clue-e. So strange. Why do people do that? I read somewhere that if a child has an alternative spelled name, teachers view the child as less intelligent.

- Mary on

congrats to them, good to hear everyone is doing well now!

I hate the name spelling. on the playground when you yell Kloey no one knows it is unique and different from Chloe, but then she will always have to spell it for everyone. It seems silly to me to change the spelling.

- Reader on

I love how everyone is attacking the way they spelled the name. Did no one read the article past the name? He says that they combined his and his wife’s names to get that spelling, so it therefore has a lot of meaning for them. It’s not because they wanted to be wacky or different. It was obviously important to them to include a little of themselves in her name, which I think is really sweet. It’s not like anyone here has to live with the name or anything, so how about instead of being nasty about it, you just keep your negatve comments to yourselves and say congrats?

Many congrats to Joey and the family on the birth of baby Kloey! I bet she is a little doll. I can’t believe how old Briahna is already! Time flys!

- Shannon on

Janet -

Stan would work :)

- JMO on

If you follow the rules of this language, then the way they spelled it actually makes more sense.

I’m glad everyone is healthy and congrats to this family!

- Jessicad on

I think the meaning for her name is sweet…she is part of mom and dad so they want her to feel it as well as see it. She will appreciate it when she is older. If she doesn’t she can change it herself. However, I get a feeling that alot of the people who comment on her name are ones while growing up who were rude to the poor kids who couldn’t help what the parents named them.

- LM on

kloey? are you kidding me? man. people with bad taste shouldn’t procrate. at least audio science is so way out there it’s kind of cool. kloey is just ridiculous and looks ugly. like rikki, it makes me think of toilets. so, you know, that’s awesome.

… but i’m glad everyone’s okay.

- sgtmian on

I feel the same way LM, just a bunch of bullies here, and their kids will sadly grow up to be the same way. It shows more bad taste to call what someone named their child ugly and ridiculous. If you don’t like it, don’t comment if you don’t have anything nice to say. I’m sure a lot of celebrities do read this, how would you feel if people bashed the name you gave your child?

- Jessicad on

No matter what you name your kid and no matter how “normal” it is spelled people will always ask ” how do you spell that?” my names Sarah and I still have to spell my simple and relatively common name out for people. My sons name is Tai only 3 freaking letters but I guarantee he will always have to spell it out, so I don’t see what the big deal is about her having to spell her name out when she gets older :/

- Sarah with an h lol on

So glad Mom and baby are okay!

ITA about the “kreatyve” spellings. I LOATHE them, which is why I picked the most simplistic spellings for my daughters.

- Mary-Helen on

Mary – I agree with you. I am a teacher and completely judge kids with ridiculously spelt names. We should not make assumptions but we all do. Chloe is a lovely name though.

- Snow on

Shannon, we did read the article and see the meaning. They could have spelled it Chloe and had the same effect of combining their names. Kelly+Joey=Chloe. They didn’t HAVE to do a creative spelling for that. No, I was not a bully. My girls aren’t bullies either. This is just a website where we share opinions like this in the comments. With their crowd and where they live it may be normal, so they probably don’t care. I wouldn’t do a creative spelling, personally.

- Reader on

Congratulations to happy parents! Thank goodness everyone is well!
May God Bless the Fatone beautiful family!

- MominMacomb on

I’ve always been more concerned about whether the name is easily pronounced. You will be asked to spell your name, no matter what it is. You just can’t be sure about spelling. I have a name that is really unusual (and made up by my parents, oh no!) and have had pronounciation issues my whole life. That was always the kicker. Because kids are way more likely to pick up on, and run with, a mispronunciation than they are to pick on a spelling. Just my own experience. Oh, and I gave my daughter a very normal name, with the traditional spelling. In her first 9 months of life her name has been misspelled three ways! Misspelling is almost inevitable these days.

- mrsh on

As far as unique spellings go, I have a doozy for ya…I worked at a store where one of the items we sold was personalized hand-painted hair clips. A woman comes in and asks if we could fit “Juliana” on a clip. I said sure, no problem, and asked her to write it on the order form. She said that her husband requested to spell the baby’s name since she picked it out, and he chose “Jewelleighannah.” Seven letters vs. fifteen? No hair clip for that baby. And no getting through kindergarten without using a forest’s worth of trees for the paper that it will take that child to learn how to write her name. Any of my business? No. Excessive and unnecessary? You bet. 

- Amanda on

Doubt the spelling matters..my best friend growing up was named Chloe, and no one could ever spell it or pronounce it. “cho-lee” or “cole-ee” was what she usually got. It may be a little different now, seeing as that was twenty years ago, but people will always ask.

- Shelly on

Reader- But, by spelling it Kloey, her name has the same last three letter as her dad’s does (oey). :)

- CelebBabyLover on

I am so glad that everything came out okay. Because giving birth is so common, often people forget about the risks.
I love the name Chloe. Although I understand where they were coming from with the name, on paper/online it looks like the name of a cartoon character.

- mochababe73 on

I like the spelling. At least that way you know how to pronounce it. And trust me, my name is Jennifer, which is pretty much as traditional as it gets, and I’ve gotten spellings like: Jeniffer and Jennipher. So you’ll always have to spell you name if you want it spelled correctly. And as for the comment about teachers judging children as being less intelligent for how their names are spelled…you have got to be kidding me!!! Teachers are supposed to be helping children learn not judging them based on something they had no control over in the first place.

- Jenn on

agree totally on the horrible spelling of a cute name. My sister adopted her foster child who’s birthname was Moneek. Yep, that was MoNEEK. She legally changed the spelling to the beautiful, traditional Monique.

- Veronica on

I usually loathe creative spellings and “unique” (i.e., made up) names. I just generally prefer traditional names. HOWEVER, I can usually make an exception where it’s a combination of the parents’ names, and I don’t think this one is too bad. Better than Maclay or Clayanne or Cash Money (or whatever the heck that kid was named). I will say though, that it has a much different “feel” than Briahnna, and I like when names of sibilings “go together” more. Briahnna is very girly; Kloey seems like a tomboyish name because of “oey” part, I think.

- Meesh on

Excuse me, it was Cash Rich. YIKES!

- Meesh on

“In addition to threatening the mother’s life, MTHFR increases the chances of the baby being born with chromosomal defects such as Down syndrome.”

NOT TRUE. Complete and utter BS. The MTHFR gene is on Chromosome 1, and CERTAIN VARIANTS of this gene produce a mutant protein which primarily affects blood clotting and folate absorption. Down Syndrome is caused by a partial or entire DUPLICATION of Chromosome 21 – totally different, and almost entirely reliant on chance rather than heredity. A woman with MTHFR has NO HIGHER RISK of having a DS baby that any other woman in the population.

How do I know this? I spoke to a genetic counselor just last Tuesday about this very gene mutation in my aunt’s family, in order to see whether I have it too. I hate it when misinformation is spread that may panic people. At worst, there is a higher risk of miscarriage due to blood clots and neural tube defects such as spina bifida or (at the absolute worst end of the spectrum) anencephaly.

Who comes up with these so-called ‘facts’?

- Margot on

Margot, dont be too sure. Methylenetetrahydrofolate reductase (MTHFR) is the name of a gene that produces an enzyme, also called methylenetetrahydrofolate reductase. If a person carries the genetic mutation that inhibits production of this enzyme, it can result in an elevated level of an enzyme called homocysteine found in blood plasma. That is called hyperhomocytenemia. When the body is deficient in methylenetetrahydrofolate reductase, its ability to absorb vitamin B9(folate), such as folic acid, is inhibited. Folic acid and B9 are both essential to the development and health of the fetus. Because of a mother with MTHFR’s inability to efficiently metabolize folic acid and vitamin B9, the disorder has been linked to a variety of pregnancy complications such as chromosomal abnormalities, including Down syndrome, and congenital malformations.

How do I know this? I am the parent of a child with Down syndrome. For 11 years, I have researched it, spoken to researchers ABOUT it, and taught others about it as well. One tried and true rule? Dont trust one Doctors take on something. Often times they are either trying to give you a short answer because they think you wont understand it more deeply, or they themselves dont understand it.

Research on your own, the connection between MTHFR and DS. You will find that cystathionine ß-synthase (CBS) deficiency IS on the 21st chromosome, it is an error of metabolism, an autosomal recessive inborn error just like MTHFR. C677T MTHFR mutation, diet, geography, age…all are clearly affecting genetic outcomes. If we understood it all completely already, we could cure DS. we cannot. The research continues. In the meantime, taking folic acid and prenatal vits has hugely impacted neural tube defects and chromosomal defects. There is a reason for that.

DOWN SYNDROME

Hobbs et al. (2000) found that the MTHFR 677C-T polymorphism is more prevalent among mothers of children with Down syndrome (190685) than among control mothers, with an odds ratio of 1.91. In addition, the homozygous MTRR 66A-G polymorphism (602568.0003) was independently associated with a 2.57-fold increase in estimated risk. The combined presence of both polymorphisms was associated with a greater risk of Down syndrome than was the presence of either alone. The 2 polymorphisms appeared to act without a multiplicative interaction. O’Leary et al. (2002) examined the prevalence of the MTHFR 677C-T variant among 48 mothers who had given birth to a child with Down syndrome and 192 control mothers. The frequency of the MTHFR 677C-T genotype was not significantly higher in mothers of children with Down syndrome (p = 0.74). However, mothers who were heterozygous or homozygous for the MTHFR variant and homozygous for the 66A-G variant in MTRR (602568.0003) had a 2.98-fold risk of having a child with Down syndrome (p = 0.02).
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607093

Hobbs et al. (2002) examined the transmission frequencies of the MTHFR 677T and 677C alleles from heterozygous parents to children with Down syndrome in 202 Caucasian families. The results indicated that the 677T allele was transmitted to children with Down syndrome at a significantly higher rate than would be expected based on mendelian inheritance patterns, and the C allele was transmitted at a significantly lower rate (P less than 0.009). The authors also examined transmission frequencies independently for maternally and paternally transmitted alleles to assess potential parent-of-origin effects. Because the vast majority of conceptions with trisomy 21 end in pregnancy loss, Hobbs et al. (2002) questioned whether the observed preferential transmission of the T allele for this population of liveborn infants with Down syndrome could reflect a survival advantage. They presented a plausible biochemical interpretation of these results based on a maternal-fetal MTHFR 677T allele interaction in the context of the constitutive overexpression of 3 copies of the cystathionine beta-synthase gene (CBS; 236200) in the trisomy 21 fetus.
these are from Johns Hopkins OMIM, the NCBI ( The National Center for Biotechnology Information) Pretty trustworthy, I would say?

- Michelle on

Congrats to the Fatone Family!!!

- Summer on

I think everyone needs to back the heck off the spelling. Guess what? I have an unusually spelled name, but I LOVE IT! It sets me apart from the other million people named Kristin/Kristen/Christen/Cristen/Cristin/Christin and I never got ridiculed for having an unusual spelling. In fact, most people I meet like the spelling. Now, if you name your kid Doorknob or Adolph, then yeah, they’ll probably be ridiculed for that. There are very few names in the world that you don’t have to spell for everyone you meet, and if you think having to spell your name is a hardship, there are a lot harder things to deal with in life than that, so don’t sweat it. I think the name Chloe is way too trendy at this point in baby-naming history, so this Kloey will probably go through school as Kloey F., just as I did as Kristyn B. Do you know how annoying it is to go through your whole life as “First Name, Last Initial” just because the name was uber-trendy at the time? But at least Kloey will feel unique and that her name has meaning for her family, unlike all the millions of people who name their kid a trendy name like Aidan or Madison just because they think it’s hip and cool, not because it has any real sentimental meaning for them. So you know what? More power to the Fatones for originality!

- Kristyn on

Very scary situation and I’m so glad the family is happy and healthy. I love the name Chloe, it is so cute. I considered this name for my daughter, but it’s getting a bit popular for my taste. IMO, the reason for her name is quite cute, but the spelling is really cheesy: Kelly + Joey = Kloey? On paper, it looks unattractive and not feminine. When spoken, it is quite pretty and feminine.

- Elsa on

I love the way they spell her name. MY grand-daughters name is spelled Emilee.

- Crickett on

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